韓曉冬:南京大學醫學院教授-中文百科頻道

人物經曆

學習經曆

1984年畢業于南京大學生物系，獲學士學位

1987年于南京大學生物系獲碩士學位

2001年，作為高級訪問學者赴美國哈佛大學醫學院

2004年于南京大學生命科學院獲博士學位

工作經曆

韓曉冬現任南京大學醫學院黨委書記，博士，組織胚胎學教授，博士生導師

主要成就

科研成就

國家自然科學基金項目（31870492）微囊藻毒素長期低劑量暴露引起小鼠學習記憶能力減退的分子機制探讨

國家自然科學基金項目（81570059）Hedgehog-Wnt信号通路參與特發性肺纖維化發病的分子機制探讨及疾病幹預的基礎研究

國家自然科學基金項目（31370524）微囊藻毒素下調雄性大鼠雄激素（睾酮)合成和分泌的機制研究

國家自然科學基金項目（30970530）微囊藻毒素低劑量長時間暴露對雄性大鼠生殖系統的影響及其機制研究

國家自然科學基金項目（81170054）調控Wnt信号通路對特發性肺纖維化發生發展影響的研究

國家自然科學基金項目（20577019）環境内分泌幹擾物烷基酚生殖毒性風險評價标準的探索

高等學校博士學科點專項科研基金（20130091110050）微囊藻毒素通過下丘腦-垂體-睾丸軸下調雄性激素合成及分泌的機制研究

江蘇省自然科學基金（BK2011570）調控WNT信号通路對特發性纖維化發生發展影響的研究

江蘇省自然科學基金（BK20151398）Hedgehog-Wnt信号通路參與特發性肺纖維化發病的分子機制探讨及疾病幹預的基礎研究

國家重點基礎研究發展計劃“973”計劃課題子項目（2010CB945103）卵巢早衰的分子機制及其早期預測、診斷生物标記的研究

國家重點基礎研究發展計劃“973”計劃課題子項目（2007CB815603）微生物群落分解礦物的機理及其對生态環境的影響

主持并參與國家自然科學基金、國家“973計劃”、教育部博士點基金、江蘇省自然科學基金等研究項目，在國内外學術刊物共發表論文180餘篇

Jin Haibo，Ma Tan，Sha Xiaoxuan，Liu Zhengyu，Zhou Yuan，Meng Xiannan，Chen Yabing，韓曉冬，Die Jie Polystyrene microplastics induced male reproductive toxicity in mice Journal of Hazardous Materials，401 (2021)-123430

Chen Yabing，Wang Jing，Xu Dihui，Xiang Zou，Ding Jie，Yang Xiaoyu，Li Dongmei，韓曉冬 m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells Autophagy，2020 Jan 31:1-19 doi-101080/1554862720201720431

Wang Jing，Chen Yabing，Zhang Changliang，Xiang Zou，Ding Jie，韓曉冬 Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR Journal of Hazardous Materials，2019，373-504–518

Wang Jing，Zhang Changliang，Zhu Jinling，Ding Jie，Chen Yabing，韓曉冬 Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR Science of the Total Environment，2019，689-662–678

Meng Xiannan，Peng Haoran，Ding Yuanzhen，Zhang Ling，Yang Jingping，韓曉冬 A transcriptomic regulatory network among miRNAs，piRNAs，circRNAs，lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity Science of the Total Environment，2019，667-563–577

Zhang Changliang，Wang Jing，Zhu Jinling，Chen Yabing,韓曉冬 Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons Science of The Total Environment 2019 Nov 1:134702 doi-101016/jscitotenv2019134702

Jin Haibo，Wang Bo，Hou Jiwei，MaTan，Qiao Dan，MiaoYingwen，Ding Jie，韓曉冬 The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons Ecotoxicology and Environmental Safety，2019，184:109614

Wang Jing，Chen Yabing，Chen Zhangpeng，Xiang Zou，Ding Jie，and 韓曉冬 Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus Ecotoxicology and Environmental Safety 2018，163:391–399

Chen Yabing，Wang Jing，Chen Xiang，Li Dongmei，韓曉冬 Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels Aquatic Toxicology 2018，199:116-126

Ding Jie，Wang Jing，Jin Haibo，Xia Tianjiao，Chen Yi，Wu Jiang，and 韓曉冬 Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice Science of the Total Environment，2018，643:496–506

Pan Chun，Chen Yabing，Xu Tianchi，Wang Jing，Li Dongmei，and 韓曉冬 Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia Environmental Pollution 2018，242-1535-1545

Hou Jiwei，Ma Tan，Cao Honghui，Chen Yabing，Wang Cong，Chen Xiang，Xiang Zou，and 韓曉冬 TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis Journal of Cellular Physiology 2018,233(3):2409-2419

Zhang Ling，Meng Xiannan，Xiang Zou，Li Dongmei，and韓曉冬 Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis Toxicological sciences，2018,161(1):159–170

Hou Jiwei，Shi Jingyan，Chen Ling，Lv Zhongyang，Chen Xiang，Cao Honghui，Xiang Zou，and 韓曉冬 M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis Cell Communication and Signaling 2018 ,16:89

Chen Xiang，Shi Chaowen，Cao Honghui，Chen Ling，Hou Jiwei，Xiang Zou，Hu Kebin，and 韓曉冬 The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis Cell Death Disease 2018,9:639

Chen Yabing，Wang Jing，Pan Chun，Li Dongmei，韓曉冬 Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8 Cellular and molecular life sciences，2018，75 (6):1117-1132

Chen Yabing，Wang Jing，Zhang Qin，Xiang Zou，Li Dongmei，韓曉冬 Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis Environmental Pollution 2017，229:964-975

Ding Jie，Wang Jing，Xiang Zou，Diao Weiyi，Su Moxi，Shi Weiwei，Wan Ting，韓曉冬 The Organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons Aquatic Toxicology 2017,182:1-10

Shi Chaowen，Cao Xiaowei，Chen Xiang，Sun Zhaorui，Xiang Zou，Zhao Hang，Qian Weiping，韓曉冬 Intracellular surface-enhanced Raman scattering probes based on TAT peptide-conjugated Au nanostars for distinguishing the differentiation of lung resident mesenchymal stem cells Biomaterials，2015 Jul; 58-10-25

Zhou Yuan，Zou Xiang，Dongmei Li，韓曉冬 Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96 Environmental Science and Technology 2014，48-6383-6390