人物經曆
學習經曆
1987年本科畢業于華中師範大學生物系
1993年碩士研究生畢業于華中師範大學昆蟲學研究所
2003年博士畢業于中山大學生科院。
工作經曆
1987年至1990年,湖北三峽大學生物系任教
1993-2000年在湖北三峽大學醫學院任教
2003-現在,暨南大學生科院任教
2009-2010,美國密西根大學癌症研究中心博士後。
主要成就
科研成就
論文
1. Wenhui Zhu, Chunyan Liu, Tongyi Lu, Yinmei Zhang, Simin Zhang, Qi Chen, Ning Deng* . Knockout of EGFL6 by CRISPR/Cas9 mediated inhibition of tumour angiogenesis in ovarian cancer. Frontiers in Oncology,. (IF4.848) 二區, | doi: 10.3389/fonc.2020.01451 July 2020
2.Chunyan Liu, Ligang Zhang, Wenhui Zhu, Raoqing Guo, Huamin Sun, Xi Chen, Ning Deng*, Barriers and strategies of cationic liposomes for cancer gene therapy, Molecular Therapy: Methods & Clinical Development. (IF4.875),二區, 2020, 18: 751-764 二區. https://doi.org/10.1016/j.omtm.2020.07.015
3. Ligang Zhang, Chengcheng Jiang, Xi Chen,Jiangtao Gu, Jin-Chen Yu,Qifang Song,Ning Deng* , Large-scale production, purification, and function of a tumor multi-epitope vaccine: Peptibody with bFGF/VEGFA. ENGINEERING IN LIFE SCIENCES. (IF1.934,三區),2020;1-15. https://doi.org/10.1002/elsc.202000020 29 July 2020
4. Ligang Zhang, Xi Chen, Yanrui Deng, Chengcheng Jiang, Ning Deng*,Fermentation, purification and immunogenicity of a recombinant tumor T multi-epitope vaccine, VBP3 . Protein Expression and Purification, 2020, 174 : 105658 . (IF 1.33,四區, doi.org/10.1016/j.pep.2020.105658, October 2020
5. Binhua Wu, Ligang Zhang, Yunfei Yu, Tongyi Lu, Yinmei Zhang, Wenhui Zhu, Qifang Song, Chengding Lv, Jiaying Guo, Yiqiao Tian and Ning Deng*. miR-6086 inhibits ovarian cancer angiogenesis by downregulating the OC2/VEGFA/EGFL6 axis, Cell Death and Disease (2020)11:345 (二區IF 5.95 ) https://doi.org/10.1038/s41419-020-2501-5, 11 MAy 2020
6. Tongyi Lu ,Binhua Wu ,Yunfei Yu ,Wenhui Zhu ,Simin Zhang ,Yinmei Zhang ,Jiaying Guo ,Ning Deng*. Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis. Cancer Science.2018 May 8. 109 (7) :2221-2234 (A1 二區, IF 4.372)(A2 四區IF1.2)
7. Ligang Zhang#, Dan He#, Jianhua Huang#, Yanrui Deng, Ruiqiang Weng, Lei Pan, Ning Deng*, The Immunogenicity and Immunoprotection of VBP3 Multi-epitope Vaccine Targeting Angiogenesis and Tumor Inhibition in Lung Cancer-Bearing Mice, International Journal of Peptide Research and Therapeutics, 2017, 12, DOI10.1007/s10989-017-9667-4
8. Yaxiong Cai, Shuange Yao, Jiangchuan Zhong, Jinxia Zhang, Haowu Jiang, Yanrui Deng, Ning Deng*. Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer. oncotarget. 2017, Vol. 8, (No. 12), pp: 20187-20197 (A1 一區 IF 5.008)
9. Yinghua Li,a Zhengfang Lin, Tiantian Xu, Changbing Wang, Mingqi Zhao, Misi Xiao, Hanzhong Wang, Ning Deng* and Bing Zhu*. Delivery of VP1 siRNA to inhibit the EV71 virus using functionalized silver nanoparticles through ROSmediated signaling pathways†. RSC Adv. 2017, 7:1453–1463 (A1 二區,IF3.289)
10. Yanrui Deng, Hui Liang, Lei Pan, Ruiqiang Weng, Ligang Zhang, Zhitao Wan, Xuejun Lao, Qing Zhang, Likuan Xiong, Ning Deng*. The Polyclonal Antibodies Induced by VBP3 Complex Peptide Targeting Angiogenesis and Tumor Suppression, International Journal of Peptide Research and Therapeutics, 2017,P1-11 (A2 四區 IF 1.0)
11. Bing Zhu, Tiantian Xu,Zhengfang Lin,Changbing Wang,Yinghua Li,Mingqi Zhao,Liang Hua,Misi Xiao,Ning Deng*,Recombinant heat shock protein 78 enhances enterovirus 71 propagation in Vero cells and is induced in SK-N-SH cells during the infection. Arch Virol. 2017,DOI 10.1007/s00705-017-3287-3 (A2 三區IF2.255)
12. Yaxiong Cai, Jinxia Zhang, Xuejun Lao, Haowu Jiang, Yunfei Yu, Yanrui Deng, Jiangchuan Zhong, Yiye Liang, Likuan Xiong and Ning Deng*, Construction of a Disulfide-stabilized diabody against FGF-2 and the Inhibition Activity in Targeting Breast Cancer,Cancer Science,2016,2016 , 107 (8) :1141-1150 (A1 二區,IF3.89,)
13. Ying Liu, Na Huang, Yunfei Yu, Chuping Zheng, Ning Deng* and Jie Liu*.Bioactive SiO2@Ru nanoparticles for osteogenic differentiation of mesenchymal stem cells via activation of Akt signaling pathways, Journal of Materials Chemistry B. 2016, DOI: 10.1039/C5TB01898F (A1 一區, IF4.726)
14. Bing Zhu, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang and Ning Deng*. Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways, Nanoscale Res Lett. 2016 Dec;11(1):198 (A1 二區,IF2.58,)
15. Shoumei Bai, Patrick Ingram, Yu-Chih Chen, Ning Deng, Alex Pearson, Yashar S. Niknafs, Patrick O'Hayer, Yun Wang, Zhong-Yin Zhang, Elisa Boscolo, Joyce Bischoff, Euisik Yoon and Ronald J. Buckanovich, EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+Ovarian Cancer Cells. Cancer Res. 2016 Nov1,76(21):6396-6409.(A1 一區 IF 8.556)
16. Chuping Zheng,Jinsheng Wang,Yanan Liu,,Qianqian Yu,Ning Deng(*),Jie Liu(*). Functional Selenium Nanoparticles Enhanced Stem CellOsteoblastic Differentiation through BMP SignalingPathways. Advanced Functional Materials. 2014,24(43): 6872–6883 (A1 一區IF 10.148,)
17. Shi, Cong Ying(#),Deng, Ning(#),Liang, Jia Jie,Zhou, Ke Nan,Fu, Qiang Qiang,Tang, Yong(*). A fluorescent polymer dots positive readout fluorescent quenching lateral flow sensor for ractopamine rapid detection,Analytica Chimica Acta,2015,854:202-208。(A1 二區,IF 4.517)
18. Qiu, Feifei; Sun, Rui; Deng, Ning; Guo, Tianyu; Cao, Yange; Yu, Ying; Wang, Xuejun; Zou, Bingcheng; Zhang, Songmei; Jing, Tao; Ling, Tao; *Xie, Jun; Zhang, Qing . miR-29a/b Enhances Cell Migration and Invasion in Nasopharyngeal Carcinoma Progression by Regulating SPARC and COL3A1 Gene Expression. PLos One, 2015, 18;10(3):e0120969. doi: (A2三區IF3.534)
19. Pan, Lei,Weng, Ruiqiang,Zhang, Jinxia,Wang, Jinsheng,Tang, Yong,Deng, Ning(*). Immune Response of the VEGF/bFGF Complex Peptide Vaccineand Function of Immune Antibodies in Inhibiting Migrationof HUVEC Cells and Proliferation of Cancer Cells.International Journal of Peptide Research and Therapeutics, 2014, 20(4): 565-574 (A2 四區IF1.2)
20. Yuan, Hailong(#),Deng, Ning(#),Zhang, Songmei,Cao, Yange,Wang, Qiong,Liu, Xin,Zhang, Qing(*). The unfolded von Willebrand factor response in bloodstream: the self-association perspective. Journal of Hematology & Oncology. 2012, 5:65-75(A1 二區,IF4.58)
21. KarenMcLean,Yusong Gong,Yunjung Choi,Silva Iness,Ning Deng,Lourdes Cabrera,Evan Keller Laurie mccauley,Kathleen Cho,Ronald Buckanovich(*),Human Ovarian Carcinoma Associated MSC Regulate Cancer Stem Cells and Tumorigenesis via Altered BMP Production,The Journal of Clinical Investigation,2011,121(8):3206-3219。doi: 10.1172/JCI45273. SCI 期刊論文(A1 一區,IF12.748)
著作:
《動物細胞工程》第二版
《動物細胞工程》
《細胞工程原理與技術》
《醫學細胞生物學》
《學細胞生物學實驗指導複習思考題》
課題
主持了國家“863”專題項目1項、國家自然科學基金3項,教育部科學技術研究重點項目1項,廣東省自然科學基金1項,廣東省科技計劃重點項目3項,廣州市科技攻關重點項目2項。
專利
獲得授權的發明專利:
美國發明專利 1 項
國際發明專利PCT 2 項
國内授權發明專利 8 項,
人才培養
主講本科學生課程:
動物細胞工程 (生物技術,生物科學,醫學生物工程)
細胞生物學(生物科學,生态學)
醫學細胞生物學(臨床醫學專業,口腔醫學專業)
主講研究生課程:
抗體工程(碩士研究生)
榮譽表彰
獲得暨南大學“十一五”優秀科研工作者,暨南大學本科教貢獻校長獎(教學綜合獎)獲得者,暨南大學生科院師德标兵等榮譽。