人物經曆
學習經曆
2004-2008博士，荷蘭萊頓大學，生物制藥系
2002-2004碩士，浙江大學，遺傳學系
1998-2002學士，浙江大學，生物技術
工作經曆
2014.12-今研究員，複旦大學，生物醫學研究院
2011.3-2014.12副研究員，複旦大學，生物醫學研究院
2008.9-2010.12博士後，荷蘭萊頓大學
主要成就
科研成果
在Mol Cell, Cell Metabolism, Cell Research, Genes & Development, EMBO J，EMBO Reports，Cell Reports等國際核心期刊共發表SCI論文30餘篇，其中第一作者或（共同）通訊作者論文19篇。科研成果被Mol Cell，EMBO J和PLOS Biology專文評述，曾在Nature, Cancer Cell等國際權威學術刊物上發表評論或綜述。
科研項目
“2011年度國家重點基礎研究發展計劃項目”（課題組長），
國家自然科學基金優秀青年科學基金項目（主持），
國家自然科學基金面上項目（主持），
上海市科委人才計劃青年啟明星計劃（主持），
上海市教委科研創新重點項目資助（主持）等。
發表論文
Xia, Y.-K., Zeng, Y.-R., Zhang, M.-L., Liu, P., Liu, F., Zhang, H., He, C.-X., Sun, Y.-P., Zhang, J.-Y., Zhang, C., Song, L., Ding, C., Tang, Y.-J., Yang, Z., Yang, C., Wang, P., Guan, K.-L., Xiong, Y., and Ye, D.* (2020) Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein & Cell（*為通訊作者）
Cheng, Z.-L., Zhang, M.-L., Lin, H.-P., Gao, C., Song, J.-B., Zheng, Z., Li, L., Zhang, Y., Shen, X., Zhang, H., Huang, Z., Zhan, W., Zhang, C., Hu, X., Sun, Y.-P., Jiang, L., Sun, L., Xu, Y., Yang, C., Ge, Y., Zhao, Y., Liu, X., Yang, H., Liu, P., Guo, X., Guan, K.-L., Xiong, Y., Zhang, M., and Ye, D.* (2020) The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports 32, 107877-107877（*為通訊作者）
Chen, X.-F., Tian, M.-X., Sun, R.-Q., Zhang, M.-L., Zhou, L.-S., Jin, L., Chen, L.-L., Zhou, W.-J., Duan, K.-L., Chen, Y.-J., Gao, C., Cheng, Z.-L., Wang, F., Zhang, J.-Y., Sun, Y.-P., Yu, H.-X., Zhao, Y.-Z., Yang, Y., Liu, W.-R., Shi, Y.-H., Xiong, Y., Guan, K.-L., and Ye, D.* (2018) SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Reports 19:e45124（*為通訊作者）
Chen, L.-L., Lin, H.-P., Zhou, W.-J., He, C.-X., Zhang, Z.-Y., Cheng, Z.-L., Song, J.-B., Liu, P., Chen, X.-Y., Xia, Y.-K., Chen, X.-F., Sun, R.-Q., Zhang, J.-Y., Sun, Y.-P., Song, L., Liu, B.-J., Du, R.-K., Ding, C., Lan, F., Huang, S.-L., Zhou, F., Liu, S., Xiong, Y. *, Ye, D.*, and Guan, K.-L. * (2018) SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Reports 25（*為通訊作者）
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z*, Ye D*, Guan KL*. (2017) L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol.37(8).（*為通訊作者）
Huai-Peng Lin, Zhou-Li Cheng, Ruo-Yu He, Lei Song, Meng-Xin Tian, Lisha Zhou, Beezly S. Groh, Weiren Liu, Min-Biao Ji, Chen Ding, Ying-Hong Shi, Kun-Liang Guan*, Dan Ye*, and Yue Xiong*. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. (2016) Cancer Research. 76(23):6924-6936.（*為通訊作者）
Ye D*, Xiong Y*. Cancer: Suffocation of gene expression. (2016) Nature. 537(7618):42-43.
Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H*, Ye D*. (2016) SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Reports. 17(6):811-22.（*為通訊作者）
Wang P, Wu J, Ma S-H, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K-L*,Ye D*, Xiong Y. (2015) Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 13(11):2353-61.（*為通訊作者）
Shiwen Wang, Bowen Jiang,Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong*, Dan Ye*, and Kun-Liang Guan*. (2015) Insulin and mTOR Pathway Regulate HDAC3-mediated Deacetylation and Activation of PGK1. PLOS Biology. 13(9):e1002243（*為通訊作者）
Previewed by: PLOS Biology.
Ma,S-H. , Jiang,B-W., Deng,W-L., Gu,Z-K., Wu,F-Z., Li,T-T., Xia,Y-K., Yang,H., Ye,D.,* Xiong, Y.,* and Guan, K-L.* (2015) D-2-Hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 6(11):8606-20.（*為通訊作者）
Hui Yang, Lisha Zhou, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang, Yi Yang, Zhi-Qiang Ling, Kun-Liang Guan*, Yue Xiong*, and Dan Ye*. (2015) SIRT3-dependent GOT2 acetylation enhances the malate-aspartate NADH shuttle activity to promote pancreatic tumor growth. EMBO J. 34(8):1110-25.（*為通訊作者）
Wang Y-P, Xiao M-T, Chen X-F, Chen L-L, Xu Y-P, Lv L, Wang P, Yang H, Ma S-H, Lin H-P, Jiao B, Ren R-B, Ye D*, Guan, K-L*, and Xiong Y*. (2015) WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 57(4):662-73.（*為通訊作者）
Previewed by: Mol Cell. Highlights in Cancer discovery
Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D*. (2014) Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 33(12):1304-20.（*為通訊作者）Previewed by: EMBO J.
Yang H. Lin H-P, Xu H-Y, Zhang L, Cheng L, Wen B, Shou J-Y, Guan K-L, Xiong Y, Ye D*. (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Research. 24(8):1017-20.（*為通訊作者）
Yang H, Liu Y, Bai F, Zhang J-Y, Ma S-H, Liu J, Xu Z-D, Zhu H-G, Ling Z-Q, Ye D*, Guan K-L* and Xiong Y*. (2013) Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. 32(5):663-9.（*為通訊作者）
Ye D, Ma S-H, XiongY , GuanK-L*. (2013) R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis. Cancer Cell. 23(3):274-276.
Wang P, Dong QZ, Zhang C, Kuan PF, Liu YF, Jeck WR, Jiang WQ, Savich GL, Tan TX, Andersen JB, J Auman JY, Hoskins JM, Misher AD, Moser CD, Yourstone SM, Kim JW, Cibulskis K, Getz G, Hunt HV, Thorgeirsson SS, Roberts LR, Ye D, Guan K-L, Xiong Y, Qin L-X*, Chiang DY*. (2013) Mutations in Isocitrate Dehydrogenase 1 and 2 are Associated with DNA Hypermethylation in Intrahepatic Cholangiocarcinomas. Oncogene. 32(25):3091-100.
Ye D*, Guan K-L* and Xiong Y*. (2012) The mechanisms of IDH mutations in tumorigenesis. Cell Research. 22 (7):1102-4.（*為通訊作者）
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D*, Xiong Y*, Guan KL. (2012) Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development. 26(12):1326-1338.（*為通訊作者）Web of ScienceTM高引論文
Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y*, Zhao S*, Guan KL*. (2012) Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab. 15(1):75-87.
Yang H, Ye D, Guan KL, Xiong Y*. (2012) IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives. Clin Cancer Res. 18(20):5562-71.
