人物經曆
教育經曆
1991-1996清華大學化學工程系，學士；
1996-2001清華大學化學工程系，博士。
工作經曆
2000-2003清華大學化學工程系，講師；
2005-2006美國麻省理工學院化學工程系，訪問學者；
2003-2012清華大學化學工程系，副教授；
2011-2016清華大學(化工系)-山東寶莫股份生物化學品聯合研究中心主任；
2012-2016清華大學化學工程系，教授、博士生導師；
2016-至今清華大學化工系教學科研系列長聘教授博士生導師。
主要成就
科研成就
發表論文
1．Miaomiao Wang, Huimin Yu*, Xu Li, Zhongyao Shen. Single-gene regulated non-spore-forming Bacillus subtilis: different patterns, transcriptome responses and applications for producing enzymes and surfactin. Metabolic Engineering, 2020. 62：235-248.
2．Youxiang Liang, Song Jiao, Miaomiao Wang, Huimin Yu* and Zhongyao Shen. A CRISPR/Cas9-based genome editing system for Rhodococcus ruber TH. Metabolic Engineering, 2020, 57: 13-22.
3．Chunmeng Xu, Lingjun Tang, Youxiang Liang, Song Jiao, Huimin Yu* and Hui Luo. Novel chaperones RrGroEL and RrGroES for activity and stability enhancement of nitrilase in Escherichia coli and Rhodococcus ruber. Molecules. 2020. 25: 1002-1016.
4．Song Jiao, Fulong Li, Huimin Yu* and Zhongyao Shen. Advances in acrylamide bioproduction catalyzed with Rhodococcus cells harboring nitrile hydratase. Applied Microbiology and Biotechnology, 2020, 104(3): 1001-1012.
5．Fangyu Cheng, HuiminYu*, Gregory Stephanopoulos*. Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid. Metabolic Engineering, 2019, 55: 276-289.
6．Miaomiao Wang*, Huimin Yu*, Zhongyao Shen. Antisense RNA-based strategy to enhance ACCase activity and surfactin production in Bacillus subtilis TS1726. ACS Synthetic Biology, 2019, 8: 251-256.
7．Lingjun Tang, Ji Yang, Jie Chen, Jing Zhang, Huimin Yu* and Zhongyao Shen. Design of salt-bridge cyclization peptide tags for stability and activity enhancement of enzymes. Process Biochemistry 2019, 81: 39-47.
8．Youxiang Liang, Song Jiao, Miaomiao Wang, Huimin Yu* and Zhongyao Shen. Overexpression of epoxide hydrolase in Rhodococcus ruber with high robustness for the synthesis of chiral epichlorohydrin. Process Biochemistry. 2019, 79: 49-56.
9．Song Jiao, Huimin Yu* and Zhongyao Shen. Core elements characterization of Rhodococcus promoters and development of a gradient intensity mini-pool for efficient gene expression. New Biotechnology, 2018, 44: 41-49.
10．Miaomiao Wang*, Jie Chen, Huimin Yu*, Zhongyao Shen. Improving stress tolerance and cell integrity of Rhodococcus ruber by overexpressing small-shock-protein Hsp16 of Rhodococcus. Journal of Industrial Microbiology & Biotechnology, 2018, 45: 929–938.
11．Yangzi Chen, Song Jiao, Miaomiao Wang, Jie Chen, Huimin Yu*. A novel molecular chaperone GroEL2 from Rhodococcus ruber and its fusion chimera with nitrile hydratase for co-enhanced activity and stability. Chemical Engineering Science, 2018, 192: 235–243.
12．Fangyu Cheng, Sijin Luozhong, Zhigang Guo, Huimin Yu* and Gregory Stephanopoulos. Enhanced biosynthesis of hyaluronic acid with engineered Corynebacterium glutamicum via metabolic pathway regulation. Biotechnology Journal. 2017, 12: 1700191.
13．Ji Yang, Fangyu Cheng, Huimin Yu*, Junting Wang, Zhigang Guo and Gregory Stephanopoulos. Key role of the carboxyl terminus of hyaluronan synthase in processive synthesis and size control of hyaluronic acid polymers. Biomacromolecules, 2017, 18: 1064−1073.
14．Song Jiao, Jie Chen, Huimin Yu*, Zhongyao Shen. Tuning and elucidation of the colony dimorphism in Rhodococcus ruber associated with cell flocculation in large scale fermentation. Appl Microbiol Biotechnol., 2017, 101: 6321-6332.
15．Song Jiao, Xu Li, Huimin Yu*, Huan Yang, Xue Li and Zhongyao Shen. In situ enhancement of surfactin biosynthesis in Bacillus subtilis using novel artificial inducible promoters. Biotechnology and Bioengineering 2017, 114(4): 832–842.
16．Shuai Zhang, Huimin Yu*, Ji Yang, Zhongyao Shen. Design of the nanoarray-pattern Fe-Ni bi-metal nanoparticles@M13 virus for enhanced reduction of p-chloronitrobenzene through micro-electrolysis effect. Environmental Science: Nano, 2017, 4: 876 - 885.
17．Jizhe Sun, Huimin Yu*, Jie Chen, Hui Luo and Zhongyao Shen. Ammonium acrylate biomanufacturing by an engineered Rhodococcus ruber with nitrilase overexpression and double-knockout of nitrile hydratase and amidase. Journal of Industrial Microbiology & Biotechnology. 2016, 43(12):1631-1639.
18．Huan Yang, Xu Li, Xue Li, Huimin Yu* and Zhongyao Shen. Identification of lipopeptide isoforms by tandem MALDI-TOF-MS/MS based on the simultaneous purification of iturin, fengycin and surfactin by RP-HPLC. Analytical and Bioanalytical Chemistry. 2015, 407(9): 2529-2542.
19．Xu Li, Huan Yang, Donglai Zhang, Xue Li, Huimin Yu* & Zhongyao Shen. Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in Bacillus subtilis. Journal of Industrial Microbiology & Biotechnology: 2015, 42(1) : 93-103.
20．Jie Chen, Huimin Yu*, Changchun Liu, Jie Liu and Zhongyao Shen. Improving stability of nitrile hydratase by bridging the salt-bridges in specific thermal-sensitive regions. Journal of Biotechnology, 2013, 164: 354–362.
人才培養
主講課程
本科生課程《生物化學原理》；
研究生課程《分子酶工程》
著作
參編教材《生物煉制技術》，譚天偉，秦培勇主編，2020；《生物反應工程原理》，曹竹安，陳堅主編，2011。
榮譽表彰
2017，高等學校科學研究優秀成果獎技術發明獎二等獎（第1完成人），教育部；
2016，東營市科學技術合作獎，東營市科技局；
2013,技術發明二等獎（第1完成人），中國石油和化學工業聯合會；
2010,青年科技突出貢獻獎，中國石油和化學工業聯合會；
2008,新世紀優秀人才，教育部；
2007,北京市科技新星（A類)，北京市科學技術委員會；
2005,華新傑出學者，清華大學；
2003,全國百篇優秀博士學位論文獎，國務院和教育部；
2003,教育部提名國家科學技術獎自然科學獎二等獎（第2完成人）。
社會任職
中國生化制藥工業協會糖類藥物分會，專家委員會專家；
歐洲生物技術協會會員；
Biochemical Engineering Journal編委；
亞洲合成生物學聯盟會員；
Biotechnology Notes副主編；
《化學與生物工程》編委。
