段樹民:中國科學院院士-中文百科頻道

人物經曆

學習經曆

1982年，段樹民畢業于蚌埠醫學院。

1982年9月－1985年8月，段樹民在南通醫學院（今南通大學）生理學專業學習，并獲碩士研究生。

1988年10月－1991年3月，獲得日本九州大學醫學部生理學專業博士研究生學位。

學習經曆

1985年9月－2000年1月，段樹民任南通醫學院航海醫學研究所教師。

1992年4月，段樹民晉升副研究員。

1995年－2001年，段樹民任航海醫學研究所副所長、航海醫學系主任。期間，1997年－1999年先後在夏威夷大學和加州大學舊金山分校做博士後研究。

2000年01月－2009年03月，段樹民在中國科學院神經科學研究所工作。期間，2000年03月，晉升研究員，後任神經科學中國重點實驗室主任、副所長。

2009年3月－2009年9月，段樹民任中國科學院神經科學研究所副所長。

2009年9月－2013年6月，段樹民任浙江大學醫學部主任。

2013年6月－2018年1月，段樹民任浙江大學醫學院院長兼醫學中心（籌）主任。

2013年，段樹民後任浙江大學醫藥學部主任。

主要成就

科研成就

科研綜述

段樹民領導的研究小組在國際上首次闡明了大腦膠質細胞突觸也具有與學習和記憶有關的可塑性。他提出經過膠質細胞介導，神經元間即使沒直接接觸也可發生相互作用，豐富了神經元環路概念。他在神經元-膠質細胞相互作用、突觸發育和功能等研究領域做出系統的創新工作，尤其在膠質細胞信号分子釋放機制、膠質細胞對神經環路和突觸可塑性的調控等方面取得研究成果。

Liu YJ*, Zhang T, Cheng DX, Yang JH,Chen SC, Wang XY, Li X, Duan D, Lou HF, Zhu LY, Luo JH, Ho M*, Wang XD*, Duan SM*. Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances. 2020 Dec 9; 6(50)eaba5783. （IF= 14.094）

Li Sun*#, Rui Liu#, Fang Guo, Man-qing Wen, Xiao-lin Ma, Kai-yuan Li, Hao Sun, Ceng-lin Xu, Yuan-yuan Li, Zheng-gang Zhu, Xinjian Li, Yan-qin Yu, Zhong Chen, Xiang-Yao Li, Shumin Duan*, Parabrachial nucleus circuit governs 1 neuropathic pain-like behavior. Nature Communications. 2020 Nov 25;11(1):5974.doi: 10.1038/s41467-020-19767-w (IF 12.123)

Bin Zhang#, Liyao Qiu#, Wei Xiao, Hong Ni, Lunhao Chen, Fan Wang, Weihao Mai, Jintao Wu, Aimin Bao, Hailan Hu, Hui Gong, Shumin Duan, Anan Li*, Zhihua Gao*. Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain, Neuron 2020 doi.org/10.1016/j.neuron.2020.10.032

Yulan Li#, Lixuan Li#, Jintao Wu, Zhenggang Zhu, Xiang Feng, Liming Qin, Yuwei Zhu, Li Sun, Yijun Liu, Zilong Qiu, Shumin Duan*,Yan-Qin Yu*.Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors. eLife 2020 9:e57155. DOI: https://doi.org/10.7554/eLife.57155

Duan D#, Zhang H#, Yue X#, Fan Y#, Xue Y, Shao J,Ding G, Li S, Cheng H, Zhang X, Chen D, Zou W, Zhao J, Wang L, Wang Z, Xu S, Duan S*, Kang L*. Sensory glia detect repulsive odorant and drive olfactory adaptation. Neuron, 2020 Sep 23; 108, 1–15

Xia Li, Liming Qin,Yefei Li, Hao Yu,Zhijun Zhang, Changlu Tao, Yijun Liu, Yanhong Xue, Xiaoxing Zhang, Zhenghao Xu, Yi Wang, Huifang Lou, Zhibin Tan, Paul Saftig, Zhong Chen, Tao Xu, Guoqiang Bi, Shumin Duan*, Zhihua Gao*. PresynapticEndosomalCathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Cell Reports. 2019 Jul 23;28(4):1015-1028.

Tan Z, Liu Y, Xi W, Lou HF, Zhu L, Guo Z, Mei L, Duan S*. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nat Commun, 2017, 8: 13772.

Yang H, Yang J, Xi W, Hao S, Luo B, He X, Zhu L, Lou H, Yu YQ, Xu F, Duan S*, Wang H*. Laterodorsaltegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.[J]. Nat Neurosci, 2016, 19(2): 283-289.

Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan S*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. J Neurosci. 2015, 35(6):2674-2688.

Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng GP, Huang ZL, Duan S*, Yu YQ*, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions, Curr Biol. 2014，24: 693-698

Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z*, Duan S. Analysis of microglial migration by a micropipette assay. Nat Protoc. 2014, 9: 491-500.

Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013, 33: 4282-93.

Chen J, Tan Z, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S*.Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. 2013, 61:178-191.

Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S*, Zheng J*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012, 30:2571-2583.

Y Dou, HJ Wu, HQ Li, S Qin, HF Lou, QM Luo, Duan S*, Microglia Migration Mediated by ATP-Induced ATP Release from Lysosome, Cell Res, 2012 22:1022-1033.

Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter for cytoplasmic transport at the axon initial segment. Cell. 2009, 136（6）:1148-1160.

Tong XP, Li XY, Zhou B, Shen WH, Zhang ZJ, Xu TL, Duan S*，Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J Cell Biol. 2009, 186（1）: 113-128.

Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2 Signaling Is Critical for Dendrite Branching. MolBiol Cell. 2008, 19(1): 4804-4813.

Zhang ZJ, Chen G, Zhou W, Song AH, Wang W, Xu T, Luo QM, Gu XS, Duan S*, Regulated ATP release from astrocytes via lysosome exocytosis. Nat Cell Biol.2007, 9(8): 945-953.

Chen G, Li HM, Chen YR, Gu XS, Duan S*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 2007; 55（15））:1509-1518.

Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, Duan S*. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science, 2006，312, 1533-1537.

Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron, 2006, 50（3）: 401-414 (Cover article)

Duan S*,Neary J, P2X7/P2Z receptors: properties and relevance to CNS functions (Invited review). Glia, 2006, 54:738-746.

Li, C., Wu, CP., Duan S*, and Poo, M*. Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron, 2004, 41(2), 257-268.

Zhang J, Wang H Ye C, Ge W, Chen Y, Wu CP, Poo M, and Duan S*.ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron,2003, 40 (5), 971-982.

Yang, Y, Ge, W, Chen, Y, Wu, CP, Poo, M, and Duan, S*. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS, 2003, 100(25), 15194-15199.

Wang, Z, Xu, N, Wu,CP, Duan S*，and Poo M*. Bidirectional Changes in Spatial Dendritic Integration Accompanying Long-Term Synaptic Modifications. Neuron, 2003, 37(3): 463-472.

Yuan X, Jin M, Xu X, Wu CP, Poo M, and Duan S*. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nat Cell Biol,2003,5 (1), 38-45.

Xiang Y, Li Y, Zhang Z, Wang S, Yuan XB, Wu CP, Poo MM and Duan S*, Nerve growth cones guidance mediated by G-protein-coupled receptors. Nat Neurosci,2002, 5, 843-848

學術論著

據2015年1月中華人民共和國教育部轉載浙江大學的一篇文章顯示：段樹民先後在《科學》《神經元》和《自然細胞生物學》等國際學術雜志上發表37餘篇文章。