韩晓冬:南京大学医学院教授-中文百科频道

人物经历

学习经历

1984年毕业于南京大学生物系，获学士学位

1987年于南京大学生物系获硕士学位

2001年，作为高级访问学者赴美国哈佛大学医学院

2004年于南京大学生命科学院获博士学位

工作经历

韩晓冬现任南京大学医学院党委书记，博士，组织胚胎学教授，博士生导师

主要成就

科研成就

国家自然科学基金项目（31870492）微囊藻毒素长期低剂量暴露引起小鼠学习记忆能力减退的分子机制探讨

国家自然科学基金项目（81570059）Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

国家自然科学基金项目（31370524）微囊藻毒素下调雄性大鼠雄激素（睾酮)合成和分泌的机制研究

国家自然科学基金项目（30970530）微囊藻毒素低剂量长时间暴露对雄性大鼠生殖系统的影响及其机制研究

国家自然科学基金项目（81170054）调控Wnt信号通路对特发性肺纤维化发生发展影响的研究

国家自然科学基金项目（20577019）环境内分泌干扰物烷基酚生殖毒性风险评价标准的探索

高等学校博士学科点专项科研基金（20130091110050）微囊藻毒素通过下丘脑-垂体-睾丸轴下调雄性激素合成及分泌的机制研究

江苏省自然科学基金（BK2011570）调控WNT信号通路对特发性纤维化发生发展影响的研究

江苏省自然科学基金（BK20151398）Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

国家重点基础研究发展计划“973”计划课题子项目（2010CB945103）卵巢早衰的分子机制及其早期预测、诊断生物标记的研究

国家重点基础研究发展计划“973”计划课题子项目（2007CB815603）微生物群落分解矿物的机理及其对生态环境的影响

主持并参与国家自然科学基金、国家“973计划”、教育部博士点基金、江苏省自然科学基金等研究项目，在国内外学术刊物共发表论文180余篇

Jin Haibo，Ma Tan，Sha Xiaoxuan，Liu Zhengyu，Zhou Yuan，Meng Xiannan，Chen Yabing，韩晓冬，Die Jie Polystyrene microplastics induced male reproductive toxicity in mice Journal of Hazardous Materials，401 (2021)-123430

Chen Yabing，Wang Jing，Xu Dihui，Xiang Zou，Ding Jie，Yang Xiaoyu，Li Dongmei，韩晓冬 m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells Autophagy，2020 Jan 31:1-19 doi-101080/1554862720201720431

Wang Jing，Chen Yabing，Zhang Changliang，Xiang Zou，Ding Jie，韩晓冬 Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR Journal of Hazardous Materials，2019，373-504–518

Wang Jing，Zhang Changliang，Zhu Jinling，Ding Jie，Chen Yabing，韩晓冬 Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR Science of the Total Environment，2019，689-662–678

Meng Xiannan，Peng Haoran，Ding Yuanzhen，Zhang Ling，Yang Jingping，韩晓冬 A transcriptomic regulatory network among miRNAs，piRNAs，circRNAs，lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity Science of the Total Environment，2019，667-563–577

Zhang Changliang，Wang Jing，Zhu Jinling，Chen Yabing,韩晓冬 Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons Science of The Total Environment 2019 Nov 1:134702 doi-101016/jscitotenv2019134702

Jin Haibo，Wang Bo，Hou Jiwei，MaTan，Qiao Dan，MiaoYingwen，Ding Jie，韩晓冬 The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons Ecotoxicology and Environmental Safety，2019，184:109614

Wang Jing，Chen Yabing，Chen Zhangpeng，Xiang Zou，Ding Jie，and 韩晓冬 Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus Ecotoxicology and Environmental Safety 2018，163:391–399

Chen Yabing，Wang Jing，Chen Xiang，Li Dongmei，韩晓冬 Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels Aquatic Toxicology 2018，199:116-126

Ding Jie，Wang Jing，Jin Haibo，Xia Tianjiao，Chen Yi，Wu Jiang，and 韩晓冬 Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice Science of the Total Environment，2018，643:496–506

Pan Chun，Chen Yabing，Xu Tianchi，Wang Jing，Li Dongmei，and 韩晓冬 Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia Environmental Pollution 2018，242-1535-1545

Hou Jiwei，Ma Tan，Cao Honghui，Chen Yabing，Wang Cong，Chen Xiang，Xiang Zou，and 韩晓冬 TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis Journal of Cellular Physiology 2018,233(3):2409-2419

Zhang Ling，Meng Xiannan，Xiang Zou，Li Dongmei，and韩晓冬 Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis Toxicological sciences，2018,161(1):159–170

Hou Jiwei，Shi Jingyan，Chen Ling，Lv Zhongyang，Chen Xiang，Cao Honghui，Xiang Zou，and 韩晓冬 M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis Cell Communication and Signaling 2018 ,16:89

Chen Xiang，Shi Chaowen，Cao Honghui，Chen Ling，Hou Jiwei，Xiang Zou，Hu Kebin，and 韩晓冬 The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis Cell Death Disease 2018,9:639

Chen Yabing，Wang Jing，Pan Chun，Li Dongmei，韩晓冬 Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8 Cellular and molecular life sciences，2018，75 (6):1117-1132

Chen Yabing，Wang Jing，Zhang Qin，Xiang Zou，Li Dongmei，韩晓冬 Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis Environmental Pollution 2017，229:964-975

Ding Jie，Wang Jing，Xiang Zou，Diao Weiyi，Su Moxi，Shi Weiwei，Wan Ting，韩晓冬 The Organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons Aquatic Toxicology 2017,182:1-10

Shi Chaowen，Cao Xiaowei，Chen Xiang，Sun Zhaorui，Xiang Zou，Zhao Hang，Qian Weiping，韩晓冬 Intracellular surface-enhanced Raman scattering probes based on TAT peptide-conjugated Au nanostars for distinguishing the differentiation of lung resident mesenchymal stem cells Biomaterials，2015 Jul; 58-10-25

Zhou Yuan，Zou Xiang，Dongmei Li，韩晓冬 Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96 Environmental Science and Technology 2014，48-6383-6390