邓宁:暨南大学教授-中文百科频道

人物经历

学习经历

1987年本科毕业于华中师范大学生物系

1993年硕士研究生毕业于华中师范大学昆虫学研究所

2003年博士毕业于中山大学生科院。

工作经历

1987年至1990年，湖北三峡大学生物系任教

1993-2000年在湖北三峡大学医学院任教

2003-现在，暨南大学生科院任教

2009-2010，美国密西根大学癌症研究中心博士后。

主要成就

科研成就

论文

1. Wenhui Zhu, Chunyan Liu, Tongyi Lu, Yinmei Zhang, Simin Zhang, Qi Chen, Ning Deng* . Knockout of EGFL6 by CRISPR/Cas9 mediated inhibition of tumour angiogenesis in ovarian cancer. Frontiers in Oncology,. (IF4.848) 二区， | doi: 10.3389/fonc.2020.01451 July 2020

2.Chunyan Liu, Ligang Zhang, Wenhui Zhu, Raoqing Guo, Huamin Sun, Xi Chen, Ning Deng*, Barriers and strategies of cationic liposomes for cancer gene therapy, Molecular Therapy: Methods & Clinical Development. （IF4.875），二区, 2020, 18: 751-764 二区. https://doi.org/10.1016/j.omtm.2020.07.015

3. Ligang Zhang， Chengcheng Jiang， Xi Chen，Jiangtao Gu， Jin-Chen Yu，Qifang Song，Ning Deng* , Large-scale production, purification, and function of a tumor multi-epitope vaccine: Peptibody with bFGF/VEGFA. ENGINEERING IN LIFE SCIENCES. （IF1.934，三区），2020;1-15. https://doi.org/10.1002/elsc.202000020 29 July 2020

4. Ligang Zhang, Xi Chen, Yanrui Deng, Chengcheng Jiang, Ning Deng*，Fermentation, purification and immunogenicity of a recombinant tumor T multi-epitope vaccine, VBP3 . Protein Expression and Purification, 2020, 174 : 105658 . （IF 1.33，四区, doi.org/10.1016/j.pep.2020.105658, October 2020

5. Binhua Wu, Ligang Zhang, Yunfei Yu, Tongyi Lu, Yinmei Zhang, Wenhui Zhu, Qifang Song, Chengding Lv, Jiaying Guo, Yiqiao Tian and Ning Deng*. miR-6086 inhibits ovarian cancer angiogenesis by downregulating the OC2/VEGFA/EGFL6 axis, Cell Death and Disease (2020)11:345 (二区IF 5.95 ) https://doi.org/10.1038/s41419-020-2501-5, 11 MAy 2020

6. Tongyi Lu ，Binhua Wu ，Yunfei Yu ，Wenhui Zhu ，Simin Zhang ，Yinmei Zhang ，Jiaying Guo ，Ning Deng*. Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis. Cancer Science.2018 May 8. 109 (7) :2221-2234 （A1 二区， IF 4.372）（A2 四区IF1.2）

7. Ligang Zhang#, Dan He#, Jianhua Huang#, Yanrui Deng, Ruiqiang Weng, Lei Pan, Ning Deng*, The Immunogenicity and Immunoprotection of VBP3 Multi-epitope Vaccine Targeting Angiogenesis and Tumor Inhibition in Lung Cancer-Bearing Mice, International Journal of Peptide Research and Therapeutics, 2017, 12, DOI10.1007/s10989-017-9667-4

8. Yaxiong Cai, Shuange Yao, Jiangchuan Zhong, Jinxia Zhang, Haowu Jiang, Yanrui Deng, Ning Deng*. Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer. oncotarget. 2017, Vol. 8, (No. 12), pp: 20187-20197 （A1 一区 IF 5.008）

9. Yinghua Li,a Zhengfang Lin, Tiantian Xu, Changbing Wang, Mingqi Zhao, Misi Xiao, Hanzhong Wang, Ning Deng* and Bing Zhu*. Delivery of VP1 siRNA to inhibit the EV71 virus using functionalized silver nanoparticles through ROSmediated signaling pathways†. RSC Adv. 2017, 7：1453–1463 （A1 二区，IF3.289）

10. Yanrui Deng, Hui Liang, Lei Pan, Ruiqiang Weng, Ligang Zhang, Zhitao Wan, Xuejun Lao, Qing Zhang, Likuan Xiong, Ning Deng*. The Polyclonal Antibodies Induced by VBP3 Complex Peptide Targeting Angiogenesis and Tumor Suppression, International Journal of Peptide Research and Therapeutics, 2017,P1-11 （A2 四区 IF 1.0）

11. Bing Zhu, Tiantian Xu，Zhengfang Lin，Changbing Wang，Yinghua Li，Mingqi Zhao，Liang Hua，Misi Xiao，Ning Deng*，Recombinant heat shock protein 78 enhances enterovirus 71 propagation in Vero cells and is induced in SK-N-SH cells during the infection. Arch Virol. 2017,DOI 10.1007/s00705-017-3287-3 （A2 三区IF2.255）

12. Yaxiong Cai, Jinxia Zhang, Xuejun Lao, Haowu Jiang, Yunfei Yu, Yanrui Deng, Jiangchuan Zhong, Yiye Liang, Likuan Xiong and Ning Deng*, Construction of a Disulfide-stabilized diabody against FGF-2 and the Inhibition Activity in Targeting Breast Cancer，Cancer Science，2016，2016 , 107 (8) :1141-1150 （A1 二区，IF3.89，）

13. Ying Liu, Na Huang, Yunfei Yu, Chuping Zheng, Ning Deng* and Jie Liu*.Bioactive SiO2@Ru nanoparticles for osteogenic differentiation of mesenchymal stem cells via activation of Akt signaling pathways, Journal of Materials Chemistry B. 2016, DOI: 10.1039/C5TB01898F （A1 一区, IF4.726)

14. Bing Zhu, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang and Ning Deng*. Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways, Nanoscale Res Lett. 2016 Dec;11(1):198 (A1 二区，IF2.58，)

15. Shoumei Bai, Patrick Ingram, Yu-Chih Chen, Ning Deng, Alex Pearson, Yashar S. Niknafs, Patrick O'Hayer, Yun Wang, Zhong-Yin Zhang, Elisa Boscolo, Joyce Bischoff, Euisik Yoon and Ronald J. Buckanovich, EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+Ovarian Cancer Cells. Cancer Res. 2016 Nov1,76(21):6396-6409.（A1 一区 IF 8.556）

16. Chuping Zheng，Jinsheng Wang，Yanan Liu,，Qianqian Yu，Ning Deng(*)，Jie Liu(*). Functional Selenium Nanoparticles Enhanced Stem CellOsteoblastic Differentiation through BMP SignalingPathways. Advanced Functional Materials. 2014,24(43): 6872–6883 （A1 一区IF 10.148，）

17. Shi, Cong Ying(#)，Deng, Ning(#)，Liang, Jia Jie，Zhou, Ke Nan，Fu, Qiang Qiang，Tang, Yong(*). A fluorescent polymer dots positive readout fluorescent quenching lateral flow sensor for ractopamine rapid detection，Analytica Chimica Acta，2015，854：202-208。(A1 二区，IF 4.517)

18. Qiu, Feifei; Sun, Rui; Deng, Ning; Guo, Tianyu; Cao, Yange; Yu, Ying; Wang, Xuejun; Zou, Bingcheng; Zhang, Songmei; Jing, Tao; Ling, Tao; *Xie, Jun; Zhang, Qing . miR-29a/b Enhances Cell Migration and Invasion in Nasopharyngeal Carcinoma Progression by Regulating SPARC and COL3A1 Gene Expression. PLos One, 2015, 18;10(3):e0120969. doi: (A2三区IF3.534)

19. Pan, Lei，Weng, Ruiqiang，Zhang, Jinxia，Wang, Jinsheng，Tang, Yong，Deng, Ning(*). Immune Response of the VEGF/bFGF Complex Peptide Vaccineand Function of Immune Antibodies in Inhibiting Migrationof HUVEC Cells and Proliferation of Cancer Cells.International Journal of Peptide Research and Therapeutics, 2014, 20(4): 565-574 （A2 四区IF1.2）

20. Yuan, Hailong(#)，Deng, Ning(#)，Zhang, Songmei，Cao, Yange，Wang, Qiong，Liu, Xin，Zhang, Qing(*). The unfolded von Willebrand factor response in bloodstream: the self-association perspective. Journal of Hematology & Oncology. 2012, 5:65-75(A1 二区，IF4.58)

21. KarenMcLean，Yusong Gong，Yunjung Choi，Silva Iness，Ning Deng，Lourdes Cabrera，Evan Keller Laurie mccauley，Kathleen Cho，Ronald Buckanovich(*)，Human Ovarian Carcinoma Associated MSC Regulate Cancer Stem Cells and Tumorigenesis via Altered BMP Production，The Journal of Clinical Investigation，2011，121（8）：3206-3219。doi: 10.1172/JCI45273. SCI 期刊论文（A1 一区，IF12.748）

著作：

《动物细胞工程》第二版

《动物细胞工程》

《细胞工程原理与技术》

《医学细胞生物学》

《学细胞生物学实验指导复习思考题》

课题

主持了国家“863”专题项目1项、国家自然科学基金3项，教育部科学技术研究重点项目1项，广东省自然科学基金1项，广东省科技计划重点项目3项，广州市科技攻关重点项目2项。

专利

获得授权的发明专利：

美国发明专利 1 项

国际发明专利PCT 2 项