人物经历
学习经历
2004-2008博士，荷兰莱顿大学，生物制药系
2002-2004硕士，浙江大学，遗传学系
1998-2002学士，浙江大学，生物技术
工作经历
2014.12-今研究员，复旦大学，生物医学研究院
2011.3-2014.12副研究员，复旦大学，生物医学研究院
2008.9-2010.12博士后，荷兰莱顿大学
主要成就
科研成果
在Mol Cell, Cell Metabolism, Cell Research, Genes & Development, EMBO J，EMBO Reports，Cell Reports等国际核心期刊共发表SCI论文30余篇，其中第一作者或（共同）通讯作者论文19篇。科研成果被Mol Cell，EMBO J和PLOS Biology专文评述，曾在Nature, Cancer Cell等国际权威学术刊物上发表评论或综述。
科研项目
“2011年度国家重点基础研究发展计划项目”（课题组长），
国家自然科学基金优秀青年科学基金项目（主持），
国家自然科学基金面上项目（主持），
上海市科委人才计划青年启明星计划（主持），
上海市教委科研创新重点项目资助（主持）等。
发表论文
Xia, Y.-K., Zeng, Y.-R., Zhang, M.-L., Liu, P., Liu, F., Zhang, H., He, C.-X., Sun, Y.-P., Zhang, J.-Y., Zhang, C., Song, L., Ding, C., Tang, Y.-J., Yang, Z., Yang, C., Wang, P., Guan, K.-L., Xiong, Y., and Ye, D.* (2020) Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein & Cell（*为通讯作者）
Cheng, Z.-L., Zhang, M.-L., Lin, H.-P., Gao, C., Song, J.-B., Zheng, Z., Li, L., Zhang, Y., Shen, X., Zhang, H., Huang, Z., Zhan, W., Zhang, C., Hu, X., Sun, Y.-P., Jiang, L., Sun, L., Xu, Y., Yang, C., Ge, Y., Zhao, Y., Liu, X., Yang, H., Liu, P., Guo, X., Guan, K.-L., Xiong, Y., Zhang, M., and Ye, D.* (2020) The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports 32, 107877-107877（*为通讯作者）
Chen, X.-F., Tian, M.-X., Sun, R.-Q., Zhang, M.-L., Zhou, L.-S., Jin, L., Chen, L.-L., Zhou, W.-J., Duan, K.-L., Chen, Y.-J., Gao, C., Cheng, Z.-L., Wang, F., Zhang, J.-Y., Sun, Y.-P., Yu, H.-X., Zhao, Y.-Z., Yang, Y., Liu, W.-R., Shi, Y.-H., Xiong, Y., Guan, K.-L., and Ye, D.* (2018) SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Reports 19:e45124（*为通讯作者）
Chen, L.-L., Lin, H.-P., Zhou, W.-J., He, C.-X., Zhang, Z.-Y., Cheng, Z.-L., Song, J.-B., Liu, P., Chen, X.-Y., Xia, Y.-K., Chen, X.-F., Sun, R.-Q., Zhang, J.-Y., Sun, Y.-P., Song, L., Liu, B.-J., Du, R.-K., Ding, C., Lan, F., Huang, S.-L., Zhou, F., Liu, S., Xiong, Y. *, Ye, D.*, and Guan, K.-L. * (2018) SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Reports 25（*为通讯作者）
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z*, Ye D*, Guan KL*. (2017) L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol.37(8).（*为通讯作者）
Huai-Peng Lin, Zhou-Li Cheng, Ruo-Yu He, Lei Song, Meng-Xin Tian, Lisha Zhou, Beezly S. Groh, Weiren Liu, Min-Biao Ji, Chen Ding, Ying-Hong Shi, Kun-Liang Guan*, Dan Ye*, and Yue Xiong*. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. (2016) Cancer Research. 76(23):6924-6936.（*为通讯作者）
Ye D*, Xiong Y*. Cancer: Suffocation of gene expression. (2016) Nature. 537(7618):42-43.
Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H*, Ye D*. (2016) SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Reports. 17(6):811-22.（*为通讯作者）
Wang P, Wu J, Ma S-H, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K-L*,Ye D*, Xiong Y. (2015) Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 13(11):2353-61.（*为通讯作者）
Shiwen Wang, Bowen Jiang,Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong*, Dan Ye*, and Kun-Liang Guan*. (2015) Insulin and mTOR Pathway Regulate HDAC3-mediated Deacetylation and Activation of PGK1. PLOS Biology. 13(9):e1002243（*为通讯作者）
Previewed by: PLOS Biology.
Ma,S-H. , Jiang,B-W., Deng,W-L., Gu,Z-K., Wu,F-Z., Li,T-T., Xia,Y-K., Yang,H., Ye,D.,* Xiong, Y.,* and Guan, K-L.* (2015) D-2-Hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 6(11):8606-20.（*为通讯作者）
Hui Yang, Lisha Zhou, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang, Yi Yang, Zhi-Qiang Ling, Kun-Liang Guan*, Yue Xiong*, and Dan Ye*. (2015) SIRT3-dependent GOT2 acetylation enhances the malate-aspartate NADH shuttle activity to promote pancreatic tumor growth. EMBO J. 34(8):1110-25.（*为通讯作者）
Wang Y-P, Xiao M-T, Chen X-F, Chen L-L, Xu Y-P, Lv L, Wang P, Yang H, Ma S-H, Lin H-P, Jiao B, Ren R-B, Ye D*, Guan, K-L*, and Xiong Y*. (2015) WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 57(4):662-73.（*为通讯作者）
Previewed by: Mol Cell. Highlights in Cancer discovery
Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D*. (2014) Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 33(12):1304-20.（*为通讯作者）Previewed by: EMBO J.
Yang H. Lin H-P, Xu H-Y, Zhang L, Cheng L, Wen B, Shou J-Y, Guan K-L, Xiong Y, Ye D*. (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Research. 24(8):1017-20.（*为通讯作者）
Yang H, Liu Y, Bai F, Zhang J-Y, Ma S-H, Liu J, Xu Z-D, Zhu H-G, Ling Z-Q, Ye D*, Guan K-L* and Xiong Y*. (2013) Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. 32(5):663-9.（*为通讯作者）
Ye D, Ma S-H, XiongY , GuanK-L*. (2013) R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis. Cancer Cell. 23(3):274-276.
Wang P, Dong QZ, Zhang C, Kuan PF, Liu YF, Jeck WR, Jiang WQ, Savich GL, Tan TX, Andersen JB, J Auman JY, Hoskins JM, Misher AD, Moser CD, Yourstone SM, Kim JW, Cibulskis K, Getz G, Hunt HV, Thorgeirsson SS, Roberts LR, Ye D, Guan K-L, Xiong Y, Qin L-X*, Chiang DY*. (2013) Mutations in Isocitrate Dehydrogenase 1 and 2 are Associated with DNA Hypermethylation in Intrahepatic Cholangiocarcinomas. Oncogene. 32(25):3091-100.
Ye D*, Guan K-L* and Xiong Y*. (2012) The mechanisms of IDH mutations in tumorigenesis. Cell Research. 22 (7):1102-4.（*为通讯作者）
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D*, Xiong Y*, Guan KL. (2012) Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development. 26(12):1326-1338.（*为通讯作者）Web of ScienceTM高引论文
Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y*, Zhao S*, Guan KL*. (2012) Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab. 15(1):75-87.
Yang H, Ye D, Guan KL, Xiong Y*. (2012) IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives. Clin Cancer Res. 18(20):5562-71.
