个人简介
汤亚杰，男，1973年10月出生，湖北武穴人，中共党员，教授，博士生导师。2003年于华东理工大学生物反应器工程国家重点实验室获生物化工博士学位，2005年从美国麻省理工学院(MIT)学成回国，长期从事“天然产物生物智造”领域的教学科研工作。
汤亚杰教授主持了科技部“中青年科技创新领军人才”、教育部“新世纪优秀人才支持计划”、湖北省“楚天学者”奖励计划、国家自然科学基金、湖北省高端人才引领培养计划等30多项科研课题。以通讯或第一作者在发酵工程领域主流学术期刊(如Scientific Reports、Metab Eng、Appl Environ Microbiol)上发表SCI论文58篇；单篇SCI他引最高达93次。以第一发明人授权发明专利18项，含美国专利2项。获湖北省科技进步一等奖1项、教育部自然科学一等奖2项、湖北省自然科学二等奖1项、上海市自然科学二等奖1项。
本着“高标准、严要求；送出去、请进来”的原则，汤亚杰时刻以自己的一言一行影响着团队成员和学生，帮助他们养成优良学风，形成独立思考、独立工作的良好习惯。坚持科研反哺教学和“以人才培养为中心，在科学研究过程中培养创新型人才”的教学思想和理念。汤亚杰把“人的发展”作为本科生教学、研究生培养和青年教师扶持的根本目标。正是由于这种创新型研究生培养模式的成功，不仅使实验室取得丰硕的科研成果，更重要的是逐渐打造了一个创新团队，武汉大学、华中科技大学、山东大学、武汉理工大学、华中农业大学、陕西师范大学等985、211院校的本科生慕名来攻读硕士学位，提升了湖北工业大学人才培养的质量与品牌。
汤亚杰应邀出任“Bioprocess and Biosystems Engineering (Springer)”副主编(Associate Editor)、Biotechnology Journal (Wiley)的Advisory Board (顾问委员会)、BioMed Research International (Hindawi)的Editorial Board (编辑委员会)。
汤亚杰享受国务院政府津贴，入选全国杰出专业技术人才、中组部“万人计划”科技创新领军人才、科技部“中青年科技创新领军人才”、人社部“新世纪百千万人才工程”国家级人选。
科研成果
汤亚杰长期从事“发酵工程”领域的科学研究，他所带领的学术团队以国家战略需求产品为导向，将发酵工程三大关键科学问题，即：微生物菌种筛选和遗传改造(上游)、发酵过程优化与放大(中游)、发酵产物分析检测与分离纯化(下游)，串联起来，联合上游、中游、下游三个方向研究力量，致力于解决实验室的生物技术成果产业化的瓶颈问题。
(1) 黑孢块菌液体深层发酵：创建了珍贵菌物资源——黑孢块菌液体深层发酵高效生产菌丝体及生物活性物质的过程，使块菌生产周期由野生的4-12年缩短为发酵的5-10天，并阐明了发酵块菌在香味、鲜味和营养组分相似或优越于野生块菌，证明了发酵块菌可替代野生块菌，为解决块菌资源短缺提供了新思路。上述研究获得国家自然科学基金(21376066、21206035)、教育部新世纪优秀人才支持计划、湖北省“楚天学者”计划等资助；部分成果发表在发酵工程领域国际知名学术期刊杂志上，如Bioresource Technology (IF=5.039)、Analytica Chimica Acta (IF=4.517)、Applied Microbiology and Biotechnology(IF=3.811)，获湖北省自然科学二等奖1项，授权发明专利4项。
(2) 鬼臼类抗肿瘤天然药物研究：构建了定向修饰鬼臼类化合物分子结构开发抗肿瘤新药的技术平台，建立了结构新颖和分子多样的“鬼臼类化合物库”，并从中筛选出一系列具有成药前景的新化合物。其中，与已应用于临床的鬼臼类抗肿瘤药物“依托泊苷”相比，4-MP-PTOX和4-TG-PTOX对人胃癌细胞株的抑制活性分别提高了121和91倍，对人正常肾小管细胞的细胞毒性分别降低了19和17倍，水溶性分别提高了300%和124%；同时，4-MP-PTOX和4-TG-PTOX具有较强的微管蛋白靶向结合能力，与靶蛋白微管蛋白的结合常数分别为8.7和8.5 μM，较“依托泊苷”(15.9 μM)均提高了近100%，有望开发为新型微管蛋白聚合抑制性抗肿瘤药物。上述研究获得科技部中青年科技创新领军人才、国家自然科学基金(20976038、20706012)等资助；部分成果发表在Bioresource Technology (IF=5.039)、Applied and Environmental Microbiology (IF=3.952)、Current Medicinal Chemistry(IF=4.070) 等国际知名学术期刊上；授权发明专利6项，含美国专利1项。
(3) 琥珀酸生物制造：建立了微生物菌种基因工程分子操作平台，对产琥珀酸大肠杆菌基因工程菌的代谢支路中关键酶基因进行了定向改造，减少了副产物合成及磷酸烯醇式丙酮酸的代谢流损失，增强了琥珀酸生物合成，琥珀酸产量提高了5倍；同时解析了琥珀酸生物合成代谢网络，筛选出影响琥珀酸通量大小的关键节点，为高产琥珀酸大肠杆菌的改造提供了新思路。上述研究获得国家自然科学基金(21176059)、湖北省自然科学基金创新群体等资助，部分成果发表在Metabolic Engineering(IF=8.258)、Microbial Cell Factories (IF=4.250)等国际知名学术期刊上。
获奖情况
1. 湖北省科技进步一等奖(2014)
2. 教育部自然科学一等奖(2014)
3. 湖北省科技进步三等奖(2013)
4. 武汉市科技进步二等奖(2013)
5. 湖北省自然科学二等奖(2011)
6. 上海市自然科学二等奖(2010)
7. 教育部自然科学一等奖(2004)
荣誉
1. 全国杰出专业技术人才(2014)
2. 中组部“万人计划”第一批科技创新领军人才(2014)
3. 科技部第一批“中青年科技创新领军人才”(2013)
4. 教育部“新世纪优秀人才支持计划”(2011)
5. 国务院政府特殊津贴(2010)
6. 人社部“新世纪百千万人才工程”国家级人选(2009)
7. 湖北省高端人才引领培养计划(2013)
8. 湖北青年五四奖章(2012)
9. 湖北省新世纪高层次人才工程“第一层次人选” (2006)
10. 湖北省优秀留学回国人员(2006)
11. 湖北省第七届青年科技奖(2006)
12. 湖北省有突出贡献中青年专家(2006)
13. 上海市研究生优秀成果(学位论文)(2004)
学术/社会兼职
1. Associate Editor: Bioprocess and Biosystems Engineering (Springer) (IF=1.823) (2012-)
2. Advisory Board: Biotechnology Journal (Wiley) (IF=3.708) (2012-)
3. Editorial Board: BioMed Research International (Hindawi) (IF=2.706) (2012-)
4. 湖北工业大学学术委员会·副主任委员(2012.6-)
5. 湖北省食品质量安全抽检监测专家委员会·副主任委员 (2014.12-)
6. 《氨基酸和生物资源》副主编(2013-)
7. 武汉大学、中国科学院武汉病毒所·兼职博士生导师(2007-)
8. 中国化工学会生物化工专业委员会·委员(2007-)
9. 湖北省微生物学会工业微生物专业委员会·主任(2009-)
10. 湖北省生物工程学会工业生物技术专业委员会·主任(2007-)
主持的科研项目
1. 2013.1-2017.12 鬼臼类抗肿瘤天然药物开发研究 科技部中青年科技创新领军人才 (国科发政[2013]452号文件)
2. 2012.1-2014.12 名贵食用菌块菌发酵过程中组分的变化规律及机制 教育部新世纪优秀人才支持计划(NCET-11-0961)
3. 2014.1-2017.12 黑孢块菌液体深层发酵产香机理 国家自然科学基金 (21376066)
4. 2012.1-2015.12 大肠杆菌基因工程菌发酵生产琥珀酸过程中CO2转运与固定的协同代谢调控 国家自然科学基金 (21176059)
5. 2013.1-2017.12 工业生物技术过程工程的关键科学问题研究 湖北省高端人才引领培养计划
6. 2006.1-2010.12 工业生物技术过程工程 湖北省“楚天学者”奖励计划
7. 2010.1-2012.12 组合生物转化鬼臼毒素产物分子多样性 国家自然科学基金(20976038)
8. 2008.1-2010.12 串联生物转化修饰鬼臼毒素分子结构的新方法研究 国家自然科学基金(20706012)
9. 2009.1-2012.1 琥珀酸生物制造的关键科学问题 湖北省自然科学基金创新群体 (2008CDA002)
10. 2006.1-2007.12 中药生物转化过程中关键问题的应用基础研究 湖北省自然科学基金青年杰出人才(2006ABB034)
发明专利
1. Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof II(US8796279B2)
2. Ya-Jie Tang. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof(US8569309B2)
3. 汤亚杰 肖黎. 具有抗肿瘤活性的酯化鬼臼类衍生物及其制备方法和用途(ZL201210374710.1)
4. 汤亚杰 白佳珂. 硫取代鬼臼类衍生物及其生物转化和分离纯化方法(ZL201110106192.0)
5. 汤亚杰 李园园. 脑苷脂的制备、纯化及含量检测方法(ZL201010268280.6)
6. 汤亚杰, 赵巍. 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用.(ZL201010156798.0)
7. 汤亚杰, 赵巍. 4-(2,3,5,6-四甲基吡嗪-1-基)-4′-去甲表鬼臼毒素的生物转化及分离纯化方法.(ZL201010159753.9)
8. 汤亚杰 张伟. 促进灵芝酸和灵芝多糖生物合成的发酵方法(ZL200810007833.5)
9. 汤亚杰 李园园. 具抗肿瘤活性的羊毛甾烷型三萜化合物及制备方法和应用(ZL200810184588.5)
10. 汤亚杰 柳巧宁. 中间补料发酵生产块菌活性菌丝体和块菌多糖的方法(ZL200810172343.0)
11. 汤亚杰 李冬生 朱丽雯. 促进灵芝次生代谢产物合成的细胞培养方法(ZL200810001055.9)
12. 汤亚杰 徐小玲 李冬生. 4′-去甲基表鬼臼酸的制备和分离方法(ZL200810002773.8)
13. 汤亚杰 李艳 李冬生. 将鬼臼毒素转化为鬼臼酸和鬼臼苦素的方法(ZL200810002774.2)
14. 汤亚杰 王冠 刘瑞桑 李冬生. α-雄烷醇的制备及含量检测方法(ZL200810000570.5)
15. 汤亚杰 张伟 李冬生. 一种促进灵芝酸和灵芝多糖生物合成的灵芝细胞培养方法(ZL200810002772.3)
16. 汤亚杰 李冬生 孔国平. 一种块菌多糖的制备方法(ZL200610166504.6)
17. 汤亚杰 李冬生 孔国平. 一种液体深层发酵生产块菌多糖的培养基(ZL200610166503.1)
18. 钟建江 汤亚杰. 中间补料发酵生产灵芝多糖和灵芝酸的方法(ZL01105700.9)
19. 汤亚杰 白佳珂. 硫取代鬼臼类衍生物及其合成方法和应用(201110106180.8)
20. 汤亚杰 肖黎. 具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途(201210374359.6)
21. 汤亚杰 陈露 赵巍. 具抗肿瘤活性的酰胺取代鬼臼类衍生物及其制备方法和用途(201310292277.1)
22. 汤亚杰 陈露 赵巍. 具有抗肿瘤活性的酯化鬼臼类衍生物及其制备方法和用途(201310292577.X)
23. 汤亚杰 李建龙 赵巍 李红梅. 硫取代鬼臼毒素类衍生物及其合成方法和应用(201310571051.5)
24. 汤亚杰 杨勇 赵巍 李红梅. 具抗肿瘤活性的苯胺基取代鬼臼类衍生物及其制备方法和用途(201310571026.7)
25. 汤亚杰 王槐 赵巍 李红梅. 具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途(201310272211.8)
26. 汤亚杰 贾开志 徐阳华 张权. 根癌农杆菌介导的黑孢块菌遗传转化方法(201410788066.1)
代表性SCI论文(第一或者通讯作者)
1.Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. The tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with antitumor antiproliferative activity. Scientific Reports (accepted) 2015 (IF=5.078)
2.Ya-Jie Tang*, Rui-Sang Liu, Hong-Mei Li. Current progress on Tuber submerged fermentation: a promising alternative for its fruiting bodies. Applied Microbiology and Biotechnology 2015, 99: 2041-2053. (IF=3.811) ( with equal contribution to this work)
3.Wei Zhao, Xiao-Hua Wang, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity fromTuber fruiting bodies and fermentation system. Applied Microbiology and Biotechnology 2014, 98:1991-2002. (IF=3.811) ( with equal contribution to this work)
4.Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways.European Journal of Medicinal Chemistry 2014, 80: 267-277. (IF=3.432) ( with equal contribution to this work)
5.Wei Zhao, Lu Chen, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan*, Ya-Jie Tang*. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014, 22:2998-3007. (IF=2.951) ( with equal contribution to this work)
6.Wei Zhao, Dan-Dan Chai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of Tuber polysaccharides produced by Tuber submerged fermentation Process Biochemistry 2014, 49: 2030-2038. (IF=2.524) ( with equal contribution to this work)
7.Li-Wen Zhu, Xiao-Hong Li, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli.Metabolic Engineering. 2013, 20:9-19 (IF=8.258) ( with equal contribution to this work)
8.Rui-Sang Liu, Huan Zhou, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum.Applied Microbiology and Biotechnology 2013, 97:9981-9992. (IF=3.811) ( with equal contribution to this work)
9.Rui-Sang Liu, Dao-Cheng Li, Hong-Mei Li, Ya-Jie Tang*. Evaluation of aroma active compounds in Tuber fruiting bodies by gas chromatography-olfactometry in combination with aroma reconstitution and omission test. Applied Microbiology and Biotechnology 2012, 94:353-363. (IF=3.811)
10. Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source. Applied Microbiology and Biotechnology 2012, 93:107-115. (IF=3.811)
11. Jia-Ke Bai, Wei Zhao, Hong-Mei Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang. Current Medicinal Chemistry 2012, 19:927-936. (IF=3.715)
12. Yuan-Yuan Li, Guan Wang, Hong-Mei Li, Jian-Jiang Zhong, Ya-Jie Tang*. Volatile organic compounds from Tuber melanosporum fermentation system. Food Chemistry 2012, 135:2628-2637. (IF=3.259)
13. Ping Liu, Hong-Mei Li, Ya-Jie Tang*. Comparison of free amino acids and 5’-nucleotides between Tuberfermentation mycelia and natural fruiting bodies.Food Chemistry 2012, 132:1413-1419. (IF=3.259)
14. Yang Tang, Hong-Mei Li, Ya-Jie Tang*. Comparison of sterol composition between Tuber fermentation mycelia and natural fruiting bodies.Food Chemistry 2012, 132:1207-1213. (IF=3.259)
15. Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Actinobacillus succinogenes ATCC 55618 fermentation medium optimization for the production of succinic acid by response surface methodology. BioMed Research International Volume2012, Article ID626137, 9 pages doi:10.1155/2012/626137 (IF=2.706)
16. Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Process Biochemistry 2012, 47:1522-1531. (IF=2.524)
17. Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Lycopene production from synthetic medium by Blakeslea trispora NRRL 2895 (+) and 2896 (-) in a stirred-tank fermenter. Bioprocess and Biosystems Engineering 2012, 35:729-749. (IF=1.823)
18. Jin-Feng Wang, Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (-). Bioprocess and Biosystems Engineering 2012, 35:553-564. (IF=1.823)
19. Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Performance analyses of a neutralizing agent combination strategy for the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Bioprocess and Biosystems Engineering 2012, 35:659-664. (IF=1.823)
20. Ping Liu, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Determination of the nucleosides and nucleobases in Tuber samples by dispersive solid-phase extraction combined with liquid chromatography–mass spectrometry.Analytica Chimica Acta. 2011, 687:159-167. (IF=4.517)
21. Wei Zou, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Significance of CO2 donor on the production of succinic acid byActinobacillus succinogenes ATCC 55618. Microbial Cell Factories. 2011, 10:87. (IF=4.250)
22. Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′- demethylepipodophyllotoxin. Applied and Environmental Microbiology2011, 77:3023-3034. (IF=3.952)
23. Yang Tang, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Comparison of lipid content and fatty acid composition between Tuber fermentation mycelia and natural fruiting-bodies. Journal of Agricultural and Food Chemistry2011, 59:4736-4742. (IF=3.107)
24. Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganodermapolysaccharides in stirred-tank bioreactor.Process Biochemistry 2011, 46: 404-408. (IF=2.524)
25. Rui-Sang Liu, Ya-Jie Tang*. Tuber melanosporum fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function. Bioresource Technology 2010, 101:3139-3146. (IF=5.039)
26. Rui-Sang Liu, Ya-Jie Tang*. Quantitative analysis for the effect of plant oil and fatty acid on Tuber melanosporumculture by uniform design combined with partial least squares regression.Applied Microbiology and Biotechnology 2010, 87: 1689-1697. (IF=3.811)
27. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum.Process Biochemistry 2010, 45:1904-1911. (IF=2.524)
28. Ya-Jie Tang*, Li-Wen Zhu. Improvement of ganoderic acid and Ganoderma polysaccharide biosynthesis byGanoderma lucidum fermentation under the inducement of Cu. Biotechnology Progress 2010, 26:417-423. (IF=1.883)
29. Li-Wen Zhu, Ya-Jie Tang*. Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides by Ganoderma lucidum.Bioprocess and Biosystems Engineering 2010, 33: 999-1005. (IF=1.823)
30. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: Process Optimization. Bioprocess and Biosystems Engineering 2010, 33:237-246. (IF=1.823)
31. Qiao-Ning Liu, Rui-Sang Liu, Yi-Hua Wang, Zhi-Yuan Mi, Dong-Sheng Li, Jian-Jiang Zhong, Ya-Jie Tang*. Fed-batch fermentation of Tuber melanosporum for the hyperproduction of mycelia and bioactive Tuber polysaccharides. Bioresource Technology 2009, 100:3644-3649. (IF=5.039)
32. Yan Li, Yuan-Yuan Li, Zhi-Yuan Mi, Dong-Sheng Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part II: Process Optimization. Bioresource Technology 2009, 100:2271-2277. (IF=5.039)
33. Ya-Jie Tang*, Wei Zhang, Jian-Jiang Zhong. Performance analyses of a pH-shift and DO-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroomGanoderma lucidum. Bioresource Technology 2009, 100:1852-1859. (IF=5.039)
34. Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Jian-Jiang Zhong. Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system. Analytica Chimica Acta 2009, 647: 40-45. (IF=4.517)
35. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463. Process Biochemistry 2009, 44:572-577. (IF=2.524)
36. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Significance of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering 2009, 32:267-276. (IF=1.823)
37. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Effect of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors.Bioprocess and Biosystems Engineering 2009, 32:475-484. (IF=1.823)
38. Ya-Jie Tang*, Yan Li, Jian-Jiang Zhong. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part I: Process Development. Bioprocess and Biosystems Engineering 2009, 32:663-671. (IF=1.823)
39. Ya-Jie Tang*, Ling-Li Zhu, Rui-Sang Liu, Hong-Mei Li, Dong-Sheng Li, Zhi-Yuan Mi. Quantitative response of cell growth and Tuber polysaccharides biosynthesis by medicinal mushroom Chinese truffle Tuber sinense to metal ion in culture medium. Bioresource Technology 2008, 99:7606-7615. (IF=5.039)
40. Guan Wang, Yuan-Yuan Li, Dong-Sheng Li, Ya-Jie Tang*. Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry. Journal of Chromatography B 2008, 870:209-215. (IF=2.694) ( with equal contribution to this work)
41. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Significance of fungal elicitors on the production of Ganodermapolysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom Ganoderma lucidum. Process Biochemistry 2008, 43:1359-1370. (IF=2.524)
42. Rui-Sang Liu, Dong-Sheng Li, Hong-Mei Li, Ya-Jie Tang*. Response surface modeling the significance of nitrogen source on the cell growth and Tuber polysaccharides production by submerged cultivation of Chinese truffle Tuber sinense.Process Biochemistry 2008, 43:868-876. (IF=2.524)
43. Ya-Jie Tang*, Ling-Li Zhu, Dong-Sheng Li, Zhi-Yuan Mi, Hong-Mei Li. Significance of inoculation density and carbon source on the mycelial growth and Tuber polysaccharides production by submerged fermentation of Chinese truffleTuber sinense. Process Biochemistry 2008, 43:576-586. (IF=2.524)
44. Wei Zhang, Ya-Jie Tang*. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides.Biotechnology Progress 2008, 24:1249-1261. (IF=1.883)
45. Ya-Jie Tang*, Hong-Mei Li, Jean-Francois P. Hamel. Suspension culture process of MethA tumor cell for the production of heat-shock protein glycoprotein 96: process optimization in spinner flasks. Biotechnology Progress2007, 23 (6):1363-1377. (IF=1.883)
46. Ya-Jie Tang*, Ryo Ohashi, Jean-Francois P. Hamel. Perfusion culture of hybridoma cell for hyperproduction of IgG2amonoclonal antibody in a wave bioreactor-perfusion culture system. Biotechnology Progress 2007, 23:255-264. (IF=1.883)
47. Ya-Jie Tang, Jian-Jiang Zhong*. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of medicinal mushroom Ganoderma lucidum. Biochemical Engineering Journal 2004, 21:259-264. (IF=2.368)
48. Ya-Jie Tang, Jian-Jiang Zhong*. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2003, 34: 478-484. (IF=2.966)
49. Ya-Jie Tang, Jian-Jiang Zhong*. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnology Progress 2003, 19:1842-1846. (IF=1.833)
50. Ya-Jie Tang, Jian-Jiang Zhong*. Fed-batch fermentation of Ganoderma lucidum for hyperproduction ofpolysaccharide and ganoderic acid. Enzyme and Microbial Technology 2002, 31: 20-28. (IF=2.966)
51. Ya-Jie Tang, Jian-Jiang Zhong*. Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, Ganoderma lucidum, grown on lactose in a bioreactor. Biotechnology Letters 2002, 24: 1023-1026. (IF=1.736)
