简历与学术成就
尹航教授1999年获得北京大学应用化学学士学位；2004年获得美国耶鲁大学化学专业博士学位；2004至2007年在美国宾夕法尼亚大学医学院从事博士后研究；加入清华大学之前于美国科罗拉多大学化学和生物化学系任终身教授。尹航教授2018年起任清华大学药学院教授、副院长，中药研究院院长，药学技术中心主任，清华大学校学术委员会委员，校学位评定委员会生物学分委会委员，生命科学联合中心高级研究员。尹航教授团队在本领域一流期刊发表研究论文超130篇，引用超过一万次；科研成果已申请专利11项（授予美国、欧盟、日本等专利4项），并有多项专利成果已经商业化。尹航教授先后获得国家自然基金委杰出青年科学基金、北京市卓越青年科学家项目、美国化学学会大卫·W·罗伯特森杰出药物化学家奖、OKeanos-CAPA资深科学家奖、中美化学及化学生物学教授联合会杰出青年教授奖、美国国家科学基金会杰出青年教授奖、美国癌症研究学会格特鲁德·B·埃利恩奖、美国癌症研究学会的SU2C创新研究奖、悉德尼·金梅尔学者奖、霍华德·休斯医学研究院合作创新奖、以及美国国家卫生研究院的 NIDA 青年化学家奖等多个奖项。尹航教授曾任国际细胞外囊泡协会执行理事、现任中国研究型医院协会细胞外囊泡分委会副主任委员、中国药学会药物化学专委会委员、《Journal of Extracellular Vesicle》(2019影响因子=14.976)责任主编、多家国际刊物编委。其实验组的成果在新华社、美国广播公司ABC、《自然》、《科学》、《美国国家科学院院刊》、美国化学会会刊《C&EN》等杂志作为“科研亮点”重点报道。培养的研究生和博士后已有多名在国内外的著名大学和科研机构独立领导研究组，前博士生Christina Boville入选MIT Technology Review Innovators Under 35全球榜单，前博士后Jonel P. Saludes现任菲律宾San Agustin大学副校长。
近期代表性论文
Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang,Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.;Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-MalarialAgents”, Proc.Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.
Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.;Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.;Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into theMalaria Parasite Plasmodium falciparum”,Cell 2020, 183, 258-268.
Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng,J.; Zhang, Y.; *Yin, H.“Immune Profiling Before Treatment is Predictive of TLR9-Induced AntitumorEfficacy”, Biomaterials 2020, 263, 120379.
Xiao, Y.; Driedonks, T.; Witwer, K.; Wang,Q.; *Yin, H. “How Does an RNASelfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J.Extracell. Vesicles 2020,9, e1793515.
Wang, Y.; Zhang,S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.;*Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055.
Jiang, S.; Tanji, H.;Yin, K.; Zhang, S.; Sakaniwa, K.; Huang, J.; Yang, Y.; Li, J.; Ohto, U.;Shimizu, T.; *Yin, H. “Rationally Designed Small-MoleculeInhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface”, J. Med. Chem. 2020, 63, 4117-4132
Gao, M.; Huang, J.;Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.;Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis toDecelerate Tumor Proliferation by Small Molecule Inhibitors Targeting GlucoseTransporters”, Protein Cell 2020, 11, 446-451.
Zhang, Y.; Jin, X.;Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote TheirCellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.
Padilla-Salinas, R.; Anderson, R.; Sakaniwa,K.; Zhang, S.; Nordeen, P.; Lu, C.; Shimizu, S.; *Yin, H. “Discovery ofNovel Small Molecule Dual Inhibitors Targeting Toll-Like Receptor 7 and 8”, J. Med.Chem. 2019, 62,10221-10244.
Tamura, R.; Balabanova, A.; Frakes, S. A.;Bargmann, A.; Koch, T. H.; *Yin, H.“Photoactivatable Prodrug ofDoxazolidine Targeting Exosomes”, J. Med. Chem. 2019, 62, 1959-1970.
Hu, Z.;Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia,A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonistsvia Structure-Based Rational Design”, CellChem. Biol. 2018, 25, 1286-1291.
Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng,K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.;Tamaki, Z.; *Yin, H.; *Varga, J.“TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skinand Lung”, JCI Insight 2018, 3, e98850.
Zhang, L.; Shi, L.; Soars, S. M.;Kamps, J.; *Yin, H. “Discovery ofNovel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory andAnti-Cancer Properties”, J. Med. Chem.2018, 61, 5881-5899.
Zhang,S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian,Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition ofTLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64.
Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Moleculesas Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem. 2017, 60, 5029-5044.
Smith, C. E.; Soti, S.; Jones, T.A.; Nakagawa, A.; Xue, D.; *Yin, H. “NSAIDs are Caspase Inhibitors”, CellChem. Biol. 2017, 24,281-292.
Das, N.; Dewan, V.; Grace, P. M.;Rosenfeld-Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 ActivatesProinflammatory Signaling via TLR5 Leading to Allodynia”, CellRep. 2016, 17,1128-1140.
*Yin, H.;Flynn, A. D. “DruggingMembrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016,18, 51-76.
Daniele, S. G.; Beraud, D.;Davenport, C.; Cheng, K.; *Yin, H.;*Maguire-Zeiss, K. A. “Activation of MyD88-Dependent TLR1/2 Signaling byMisfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45.
Cheng, K.; Gao, M.; Godfroy III, J. I.; Brown, P. N.; Kastelowitz, N.; *Yin, H.“Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139.
Smith, C. E.; Wang, X.H.; *Yin, H. “Caspases Come TogetherOver LPS”, Trends Immunol. 2015,36, 59-61.
Csakai, A.; Smith, C.; Davis, E.;Martinko, A.; Coulup, S.; *Yin, H. “SaccharinDerivatives as Inhibitors of Interferon-Mediated Inflammation”, J. Med. Chem. 2014, 57, 5348-5355.
Wang, X. H.; Smith, C.; *Yin, H. “Targeting Toll-LikeReceptors with Small Molecule Agents”, Chem.Soc. Rev. 2013, 42, 4859-4866.
Morton, L. A.; Yang, H.; Saludes, J. P.; Fiorini, Z.; Beninson, L.;Chapman, E. R.; Fleshner, M.; Xue, D.; *Yin,H. “MARCKS-ED Peptide as a Membrane Curvature Sensor”, ACS Chem. Biol. 2013, 8, 218-225.
Cheng, K.; Wang, X. H.; Zhang, S.; *Yin,H.“Discovery ofSmall-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”, Angew. Chem. Int. Ed. 2012, 51, 12246-12249.
Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E.R.; Fleshner, M.; *Yin, H. “Detectionof Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived fromSynaptotagmin-I”, ACS Chem. Biol. 2012,7, 1629-1635.
Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng,K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “Morphine Activates Neuroinflammation in a Parallel Manner toEndotoxin”, Proc. Natl. Acad. Sci. U. S.A. 2012, 109, 6325-6330.
Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.;Mollnes, T. E.; *Yin, H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated InflammatoryResponse as Potential Antiseptics”, J. Med.Chem. 2011, 54, 4659-4669.
Cheng, K.; Wang, X. H.; *Yin,H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”, J. Am. Chem. Soc. 2011, 133, 3764-3767.
*Yin, H. “ExogenousAgents that Target Transmembrane Domains of Proteins”, Angew. Chem. Int. Ed. 2008,47, 2744-2752.
Yin, H.; Slusky, J. S; Berger, B. W.;Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo, G.A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides thatTarget Transmembrane Helices”, Science2007, 315, 1817-1822.
