人物经历

2002年本科毕业后，尹烨加入华大集团（以下简称：华大）子公司——北京华大吉比爱生物技术有限公司，先后从事体外诊断试剂研发、产品注册、生产管理、质量管理、市场营销等工作，在生物产品研发、生产、质控、申报注册及生物技术临床应用推广等方面有丰富的经验，主持申报数十项体外诊断试剂及多项专利，对于GMP/IVD/ISO系列质量管理体系有深刻理解。n

2003年春，尹烨作为“非典型性肺炎”（SARS）早期诊断科研攻关的主要参与者之一，在华大高效完成SARS病毒测序和获得诊断蛋白之后，率领团队在24小时内即完成了SARS诊断试剂盒研发及申报材料的准备，并顺利获得了国药局（现食药总局）的审批。随后，华大及时将30万人份SARS检测试剂盒无偿捐赠给国家非典防治指挥部，对疫情的防控起到了关键性作用。

2009年，尹烨调入华大集团深圳总部，负责基因组学及生物信息学全球范围内的产业推广，并先后出任华大基因科技合作事业部总裁、全球基因组平台负责人、华大生命科学研究院助理院长、华大集团首席运营官、华大医学执行总裁等职。

2010年起，他开始组建华大全球营销团队，打造华大全球化科研、产业平台，完成了华大的全球化布局。期间，尹烨主持或参与了上百个国际基因组合作项目，包括“千种动植物基因组计划”“百万人重测序计划”“蒙古族人基因组计划”等大型项目，在Nature系列、Science、PNAS等国际顶级学术期刊发表近60篇论文（详见主要论文部分），并促成华大与全球生命科学相关领域的机构建立良好的合作关系，为推动基因组学研究、分子育种、医疗健康、环境能源等领域的科研发展做出重要贡献。

2013年，尹烨作为核心成员，参与完成华大对美国上市公司Complete Genomics的全资收购。

2014年，尹烨出任华大医学执行总裁，全面贯彻“5P医学”理念，降低出生缺陷及减少肿瘤等重大疾病对人类健康的危害，推动全球基因检测的临床应用发展。

2017年7月14日，深圳华大基因股份有限公司在创业板上市，成为中国基因科技第一股。尹烨任深圳华大基因股份有限公司CEO，率领团队积极推动前沿生物技术和基因组学研究成果的产业化应用，向全球顶尖的医疗机构、科研机构、大学、药厂、育种公司等提供完整的基因组学解决方案，为临床行为提供诊断、干预和治疗依据，为生命科学及医学创新提供技术和研究服务，和团队一起致力于使华大基因成为全球基因科技、临床应用的行业领导者。

公益实践

在尹烨的带领下，华大基因一直积极践行改善人类健康的社会责任，心系公益事业。他与团队发起“生命周期表”等项目及活动，长期支持中国罕见病发展中心等罕见病专业组织，带领团队发起并组建“同并相联”网站，以期打造成为罕见病、遗传病诊治与交流第一平台。与团队多次发起罕见病救助项目，致力于推动对罕见病、血液疾病的关爱与救助。

尹烨个人亦带头捐款发起成立公益基金——华基金，永久免费为重症地贫患儿提供HLA配型；牵头发起成立“爱之光眼病基因检测”“光基金”，意在免费提供基因检测救助先天性眼疾的患者；发起成立“狂犬病科研基金”等专项基金，旨在推进狂犬病治疗的临床研究。

尹烨积极参与基因科普工作，多次受邀在WIRED、TEDx、一席、中国企业家论坛、亚布力企业家论坛、中欧EMBA、长江EMBA、北大EMBA、湖南卫视《我是未来》、混沌研习社、黑马营、科技部人才中心、深圳市市民大讲堂等平台授课，并在喜马拉雅FM、懒人听书等新媒体开设“天方烨谈”基因科普栏目，通过多种渠道和途径、上百集节目、上百篇文章，讲大众听得懂的生命科学，宣传、推广与广大人民群众相关的基因技术与知识。

主要论文

Wang X, Wang H, Wang J,…, Yin Y…, Brassica rapa Genome Sequencing Project Consortium. (2011) The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics. 2011 Aug 28;43(10):1035-9.

岳桂东，高强，罗龙海，王军一，许娇卉，尹烨 （2012） 高通量测序技术在动植物研究领域中的应用.中国科学，42(2): 107-124.

Gao Q, Yue GD, Li WQ, Wang JY, Xu JH, Yin Y. (2012) Recent progress using high-throughput sequencing technologies in plant molecular breeding. Journal of Integrative Plant Biology, 54(4):215-27.

Qiu Q, Zhang G, Ma T,…, Yin Y, ….(2012) The yak genome and adaptation to life at high altitude. Nature Genetics. 2012 Jul 1;44(8):946-9.

Kunbo Wang, Zhiwen Wang, Fuguang Li, …, Ye Yin,…. (2012) The draft genome of a diploid cotton Gossypium raimondii. Nature Genetics. 2012 Aug 26; 44(10):1098–1103

Zhang G, Fang X, Guo X, …, Yin Y, Wang J. (2012) The oyster genome reveals stress adaptation and complexity of shell formation.Nature. 2012 Oct 4;490(7418):49-54.

David M Altshuler, Richard M Durbin, Goncalo R Abecasis...Yin Y...(2012)An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 November 1; 491(7422): 56–65.

Shaogui Guo, Jianguo Zhang, Honghe Sun, …, Ye Yin, ….(2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nature Genetics. 2012 Nov 25; 45(1):51–58

Yin Y, Yue GD, Gao Q, Wang ZY,... (2012) Genome Sequence of Pedobacter arcticus sp. nov., a Sea Ice Bacterium Isolated from Tundra Soil. Journal of Bacteriology, 2012 Dec;194 (23):6688.

Qixiang Zhang, Wenbin Chen, Lidan Sun, …,Ye Yin, …(2012) The genome of Prunus mume.Nature Communications, 2012,DOI: 10.1038/ncomms2290

Xiangjiang Zhan, Shengkai Pan, Junyi Wang, …, Ye Yin, …(2013) Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle.Nature Genetics. 2013 March 24;45(5): 563–566

Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa,…, Ye Yin, Bronwen Aken, Guojie Zhang& Naoki Irie.(2013) The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics. 2013 April28;10.1038/ng.2615

Jinfeng Chen, Quanfei Huang, Dongying Gao...Ye Yin...(2013)Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution. Nature Communications, 2013, DOI: 10.1038/ncomms2596

Yabin Chen, Qingyan Zhang,Tao Shen … ,Ye Yin, …. （2013）Comprehensive mutation analysis by whole-exome sequencing in 41 Chinese families with Leber congenital amaurosisInvest . Ophthalmol Vis Sci. 2013 May 9（共同作者）

Huang L1, Zhang Q, Li S, Guan L, Xiao X, Zhang J, Jia X, Sun W, Zhu Z, Gao Y, Yin Y, Wang P, Guo X, Wang J, Zhang Q.(2013) Exome sequencing of 47 chinese families with cone-rod dystrophy: mutations in 25 known causative genes. PLoS One. 2013 Jun 11; 8(6):e65546.

Xiaosen Guo, Max Brenner, Xuemei Zhang, ..., Ye Yin, ... (2013) Whole-Genome Sequences of DA and F344 Rats with Different Susceptibilities to Arthritis,Autoimmunity, Inflammation and Cancer. Genetics, August 2013, 194(4):1017-28

Zhang C1, Li D, Zhang J,..., Yin Y, ....（2013）Mutations in ABCB6 cause dyschromatosis universalis hereditaria. J Invest Dermatol. 2013 Sep;133(9):2221-8.

Tao Ma,Junyi Wang,Gongke Zhou, … ,Ye Yin, …(2013) Genomic insights into salt adaptation in a desert poplar. Nature Communications,2013, doi:10.1038/ncomms3797.

Xiao JH, Yue Z, Jia LY, ..., Yin Y...(2013)Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology,2013,14:R141 doi:10.1186

Cheng Qin, Changshui Yu, Yaou Shen, …, Ye Yin, Jiping Yu, Kailin Hu, and Zhiming Zhang.(2014) Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. PANS, 2014,doi/10.1073/pnas.1400975111

Udpa N, Ronen R, Zhou D,..., Yin Y...(2014)Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biology. 2014 Feb 20;15(2):R36.

Shiqiang Li, Liping Guan, Shaohua Fang, ..., Ye Yin, ...(2014) Exome sequencing reveals CHM mutations in six families with atypical choroideremia initially diagnosed as retinitis pigmentosa. International Journal of Molecular Medicine,2014 June 6, DOI: 10.3892

Xu Y1, Guan L, Shen T, ..., Yin Y, Guo X, Wang J, Zhang Q.(2014) Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing. Hum Genet. 2014 Jun 18.

Su Z, Labaj PP, Li S, ..., Yin Y, ... (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology. 2014 Sep; 32(9):903-14.

Xinfen Yu, Tao Jin, Yujun Cui, ..., Ye Yin, ...(2014) Coexistence of influenza H7N9 and H9N2 in poultry linked to human H7N9 infection and their genome characteristics. journal of Virology. 2014 Mar, 88(6):3423-31.

Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh...Ye Yin,...(2014)Camelid genomes reveal evolution and adaptation to desert environments. Nature Communications. 21 October 2014, doi:10.1038/ncomms6188

Haihua Bai, Xiaoshen Guo, Dong Zhang, ... Ye Yin,...(2014)The genome of a mongolian individual reveals the genetic imprints of mongolians on modern human populations.Genome Biology and Evolution. 5 November 2014, 6(12):3122-3136

Xiangyu Ma, Liping Guan, Wei Wu,...Ye Yin, ...(2015) Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. Scientific Report. 2015 Mar 18;5:9236. doi: 10.1038/srep09236.

Zhang H1, Gao Y, Jiang F,...Yin Y,...(2015)Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146 958 pregnancies. Ultrasound Obstet Gynecol. 2015; 45: 530–538

Published online 8 April 2015 in Wiley Online Library . DOI:10.1002/uog.14792.